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新冠肺炎-免疫学解决方案

日期：2020年3月30日 浏览次数：13,925

      2019新型冠状病毒（2019-nCoV），因2019年武汉病毒性肺炎病例而被发现，2020年1月12日被世界卫生组织命名。由于该新型冠状病毒传染性强，人群普遍易感，在人群中广为传播，迅速蔓延至全国。在政府和国人的努力下，国内疫情高峰已过，对于新冠致病机理的研究也拉开了序幕。流式细胞术，高通量液相蛋白芯片，ELISA，ELISPOT和多聚体将为新冠机制研究和药物的研发提供免疫学解决方案。

流式检测

      新冠诊疗方案中的描述：外周血淋巴细胞计数进行性降低；淋巴细胞中B淋巴细胞明显降低，CD4及CD8 T细胞不断下降。《柳叶刀》2月17日发表首例对新冠肺炎死亡患者病理解剖的分析报告中，外周血流式细胞术分析发现，外周血CD4+和CD8+细胞的数量大大减少，而它们的状态却被过度激活。T细胞参与细胞免疫反应，B细胞参与体液免疫反应，淋巴细胞亚群分析是检测细胞免疫和体液免疫功能的重要指标，它总体反映机体当前的免疫功能、状态和平衡水平，对分析发病机制，观察疗效及检测预后有重要意义。

检测目标

指标

荧光染料

克隆号

货号

T细胞

CD3

APC

UCHT1

20-0038

CD4

PE

OKT4

50-0048

CD8a

FITC

HIT8a

35-0089

B细胞

CD3

FITC

UCHT1

35-0038

CD19

APC

HIB19

20-0199

NK细胞

CD16

APC

3G8

20-0166

CD56

PE

CMSSB

12-0567

NKT细胞

CD3

FITC

UCHT1

11-0038

CD56

APC

MY31

20-0564

Th1/Th2/Th17细胞

CD4

FITC

RPA-T4

35-0049

IFN-gamma

PerCP-Cy5.5

4S.B3

45-7319

IL-4

PE

MP4-25D2

50-7048

IL-17A

APC

eBio64DEC17

17-7179

Th9/Th22细胞

CD4

FITC

RPA-T4

35-0049

IL-9

PE

MH9D1

12-7098

IL-22

APC

22URTI

17-7229

Tfh细胞

CD4

FITC

RPA-T4

35-0049

CD185(CXR5)

APC

MU5UBEE

17-9185

CD278(ICOS)

PerCP-eFluor® 710

ISA-3

46-9948

CD279(PD-1)

PE

J110

50-2797

Treg细胞

CD4

FITC

RPA-T4

35-0049

CD25

APC

BC96

20-0259

Foxp3

PE

PCH101

12-4776

CD127

PE

eBioRDR5

12-1278

Breg细胞

CD19

APC

HIB19

20-0199

CD5

FITC

L17F12

35-0058

CD1d

PerCP-eFluor® 710

51.1

46-0016

IL-10

PE

JES3-9D7

12-7108

单核细胞

CD14

APC

61D3

20-0149

★  巨噬细胞

CD11b[

FITC

ICRF44

35-0118

CD68

PE

Y1/82A

12-0689

CD163

APC

GHI/61

17-1639

★  DC细胞

CD80

FITC

2D10.4

35-0809

CD83

PE

HB15e

12-0839

CD86

PE-Cyanine7

IT2.2

25-0869

HLA-DR

APC-Cyanine7

L243

25-9952

CD11c

violetFluor 450

3.9

75-0116

CD123

APC

6H6

17-1239

注：★细胞来源不同，Marker不同

细胞因子风暴检测

      细胞因子风暴（cytokine storm）是指机体感染微生物后引起体液中多种细胞因子如TNF-α、IL-1、IL-6、IL-12、IFN-α、IFN-β、IFN-γ、MCP-1和IL-8等迅速大量产生的现象，是引起急性呼吸窘迫综合症和多器官衰竭的重要原因。

      免疫系统的日常工作是清除感染，但是现今大量的2019-nCoV对人体产生攻击，导致人体免疫系统紊乱，进而伤害宿主。这种极端的免疫攻击行为是“细胞因子风暴”。

      1月14日，权威期刊《柳叶刀》发表的新冠病毒感染的首批病例临床数据报告显示，细胞因子风暴与疾病的严重程度有关。1月29日，《柳叶刀》发表的99例患者研究中，一些重症的患者体内产生了严重的细胞因子风暴。高通量液相蛋白芯片可以监测细胞因子风暴，辅助疾病诊断和治疗。

货号

产品名称

指标

EPX650-10065-901

Immune Monitoring 65-Plex Human Panel

APRIL, BAFF, BLC, CD30, CD40L, ENA-78, Eotaxin, Eotaxin-2, Eotaxin-3, FGF-2, Fractalkine, G-CSF, GM-CSF, Gro a, HGF, IFN-a, IFN-g, IL-10, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IL-18, IL-1a,IL-1b, IL-2, IL-20, IL-21, IL-22, IL-23, IL-27, IL-2R, IL-3, IL-31, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IP-10, I-TAC, LIF, MCP-1, MCP-2, MCP-3, M-CSF, MDC, MIF, MIG, MIP1a, MIP-1b, MIP-3a, MMP-1,NGF beta, SCF, SDF-1a, TNF b, TNF-a, TNF-R2, TRAIL, TSLP, TWEAK, VEGF-A

EPX450-12171-901

Cytokine/Chemokine/Growth Factor Convenience 45-Plex Human Panel

BDNF, EGF, Eotaxin, FGF-basic, GM-CSF, GROα, HGF, IFNγ, IFNα, IL-1RA, IL-1β, IL-1α, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 p70, IL-13, IL-15, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10, LIF, MCP-1, MIP-1α, MIP-1β, NGFβ, PDGF-BB, PLGF, RANTES, SCF, SDF1α, TNFα, TNFβ, VEGF-A, VEGF-D

EPX340-12167-901

Cytokine & Chemokine Convenience 34-Plex Human Panel

Eotaxin, GM-CSF, GROα, IFNα, IFNγ, IL-1β, IL-1α, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-9, IL-10, IL-12 p70, IL-13, IL-15, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10, MCP-1, MIP-1α, MIP-1β, RANTES, SDF1α, TNFα, TNFβ

EPX200-12185-901

Inflammation 20-Plex Human Panel

E-Selectin, GM-CSF, ICAM-1, IFNα, IFNγ, IL-1α, IL-1β, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IP-10, MCP-1, MIP-1α, MIP-1β, P-Selectin, TNFα

 

细胞因子定量检测

      对于病毒感染的细胞因子定量检测，我们有多个品牌的ELISA试剂盒可选。

      Thermo/Invitrogen /eBio ELISA试剂盒

抗病毒因子

货号

产品名称

规格

备注

IFN-alpha

411001

HUMAN IFN ALPHA ELISA（supernatant）

96 tests

已包被

411002

HUMAN IFN ALPHA ELISA（supernatant）

5 x 96 tests

411101

HUMAN IFN ALPHA （supernatant）

96 tests

411102

HUMAN IFN ALPHA （supernatant）

5 x 96 tests

BMS216

HU IFN A COATED ELISA

96 tests

BMS216INST

HU IFN A INSTANT ELISA

128 tests

BMS216TEN

HU IFN A COATED ELISA

10 x 96 tests

IFN-beta

414101

PIERCE HUMAN IFN BETA ELISA（supernatant）

96 tests

已包被

IFN-gamma

88-7316-22

HU IFN G UNCOATED ELISA

2 x 96 tests w/plates

未包被

88-7316-76

HU IFN G UNCOATED ELISA

20 x 96 tests w/plates

88-7316-77

HU IFN G UNCOATED ELISA

20 x 96 tests

88-7316-86

HU IFN G UNCOATED ELISA

10 x 96 tests w/plates

88-7316-88

HU IFN G UNCOATED ELISA

10 x 96 tests

KAC1231

HU IFN GAMMA ELISA KIT

96 tests

已包被

KHC4021

HU IFN GAMMA ELISA KIT

96 tests

KHC4021C

HU IFN GAMMA ELISA KIT

5 x 96 tests

KHC4022

HU IFN GAMMA ELISA KIT

2 x 96 tests

EHIFNG2

HUMAN IFN GAMMA ELISA (2-PAK)

2 x 96 tests

EHIFNG5

HUMAN IFN GAMMA ELISA (5-PAK)

5 x 96 tests

ESS0002

HUMAN IFN GAMMA REAGENT KIT

5 x 96 tests

未包被

IL-12P40

KAC1561

HU IL 12 P40 ELISA KIT

96 tests

已包被

TNF-alpha

88-7346-22

HU TNF A UNCOATED ELISA

2 x 96 tests

未包被

88-7346-76

HU TNF A UNCOATED ELISA

20 x 96 tests w/plates

88-7346-77

HU TNF A UNCOATED ELISA

20 x 96 tests

88-7346-86

HU TNF A UNCOATED ELISA

10 x 96 tests w/plates

88-7346-88

HU TNF A UNCOATED ELISA

10 x 96 tests

BMS2034

HU TNF A TOTAL COATED ELISA

96 tests

已包被

BMS2034TEN

HU TNF A TOTAL COATED ELISA

10 x 96 tests

BMS223INST

HU TNF A INSTANT ELISA

128 tests

KAC1751

HU TNF ALPHA ELISA KIT

96 tests

KHC3011

HU TNF ALPHA ELISA KIT

96 tests

KHC3011C

HU TNF ALPHA ELISA KIT

2 x 96 tests

KHC3012

HU TNF ALPHA ELISA KIT

5 x 96 tests

KHC3013

HU TNF ALPHA US ELISA KIT

2 x 96 tests

KHC3014

HU TNF ALPHA US ELISA KIT

96 tests

KHC3014C

HU TNF ALPHA US ELISA KIT

5 x 96 tests

IL-1beta

88-7261-22

HU IL-1 B UNCOATED ELISA

2 x 96 tests w/plates

未包被

88-7261-76

HU IL-1 B UNCOATED ELISA

20 x 96 tests w/plates

88-7261-77

HU IL-1 B UNCOATED ELISA

20 x 96 tests

88-7261-86

HU IL-1 B UNCOATED ELISA

10 x 96 tests w/plates

88-7261-88

HU IL-1 B UNCOATED ELISA

10 x 96 tests

BMS224INST

HU IL-1 B INSTANT ELISA

128 tests

已包被

KAC1211

HU IL 1BETA ELISA KIT

96 tests

KHC0011

HU IL 1BETA ELISA KIT

96 tests

KHC0011C

HU IL 1BETA ELISA KIT

5 x 96 tests

KHC0012

HU IL 1BETA ELISA KIT

2 x 96 tests

IL-2

88-7025-22

HU IL-2 UNCOATED ELISA

2 x 96 tests w/plates

未包被

88-7025-76

HU IL-2 UNCOATED ELISA

20 x 96 tests w/plates

88-7025-77

HU IL-2 UNCOATED ELISA

20 x 96 tests

88-7025-86

HU IL-2 UNCOATED ELISA

10 x 96 tests w/plates

88-7025-88

HU IL-2 UNCOATED ELISA

10 x 96 tests

BMS221INST

HU IL-2 INSTANT ELISA

128 tests

已包被

EH2IL2

PIERCE HUMAN IL-2 ELISA KIT

96 tests

EH2IL22

PIERCE HUMAN IL-2 ELISA KIT

2 x 96 tests

EH2IL25

PIERCE HUMAN IL-2 ELISA KIT

5 x 96 tests

IL-6

88-7066-22

HU IL-6 UNCOATED ELISA

2 x 96 tests

未包被

88-7066-76

HU IL-6 UNCOATED ELISA

20 x 96 tests w/plates

88-7066-77

HU IL-6 UNCOATED ELISA

20 x 96 tests

88-7066-86

HU IL-6 UNCOATED ELISA

10 x 96 tests w/plates

88-7066-88

HU IL-6 UNCOATED ELISA

10 x 96 tests

BMS213-2

HU IL-6 COATED ELISA

96 tests

已包被

BMS213-2MST

HU IL-6 MATCHED PAIR

10 x 96 tests

BMS213-2TEN

HU IL-6 COATED ELISA

10 x 96 tests

BMS213HS

HU IL-6 HS COATED ELISA

96 tests

BMS213INST

HU IL-6 INSTANT ELISA

128 tests

IL-18

BMS267INST

HU IL-18 INSTANT ELISA

128 tests

已包被

KHC0181

HU IL 18 ELISA KIT

96 tests

      TONBO Biosciences ELISA试剂盒

抗病毒因子

货号

产品名称

规格

备注

IL-2

41-9222-P002

Human IL-2 ELISA Matched Antibody Pair Kit

2 plates

未包被

41-9222-P010

Human IL-2 ELISA Matched Antibody Pair Kit

10 plates

IL-6

41-9224-P002

Human IL-6 ELISA Matched Antibody Pair Kit

2 plates

41-9224-P010

Human IL-6 ELISA Matched Antibody Pair Kit

10 plates

TNF-alpha

41-9226-P002

Human TNF-alpha ELISA Matched Antibody Pair Kit

2 plates

41-9226-P010

Human TNF-alpha ELISA Matched Antibody Pair Kit

10 plates

IFN-gamma

41-9227-P002

Human IFN-gamma ELISA Matched Antibody Pair Kit

2 plates

41-9227-P010

Human IFN-gamma ELISA Matched Antibody Pair Kit

10 plates

IL-1beta

41-9237-P002

Human IL-1beta ELISA Matched Antibody Pair Kit

2 plates

41-9237-P010

Human IL-1beta ELISA Matched Antibody Pair Kit

10 plates

IL-12

41-9238-P002

Human IL-12 ELISA Matched Antibody Pair Kit

2 plates

41-9238-P010

Human IL-12 ELISA Matched Antibody Pair Kit

10 plates

注：ELISA Matched Antibody Pair Kit+ELISA Buffer Kit（41-9245-KIT）才能完成实验

      Mabtech ELISA试剂盒

抗病毒因子

货号

产品名称

规格

备注

IL-1beta

3416-1A-20

Human IL-1beta ELISA development kit (ALP)

for 20 plates

未包被

3416-1A-6

Human IL-1beta ELISA development kit (ALP)

for 6 plates

3416-1H-20

Human IL-1beta ELISA development kit (HRP)

for 20 plates

3416-1H-6

Human IL-1beta ELISA development kit (HRP)

for 6 plates

3416-1HP-10

Human IL-1beta ELISAPRO kit

10 plates

已包被

3416-1HP-2

Human IL-1beta ELISAPRO kit

2 plates

IFN-gamma

3420-1A-20

Human IFN-gamma ELISA development kit (ALP)

for 20 plates

未包被

3420-1A-6

Human IFN-gamma ELISA development kit (ALP)

for 6 plates

3420-1H-20

Human IFN-gamma ELISA development kit (HRP)

for 20 plates

3420-1H-6

Human IFN-gamma ELISA development kit (HRP)

for 6 plates

3420-1HP-10

Human IFN-gamma ELISAPRO kit

10 plates

已包被

3420-1HP-2

Human IFN-gamma ELISAPRO kit

2 plates

IFN-alpha2

3423-1A-20

Human IFN-alpha2 ELISA development kit (ALP)

for 20 plates

未包被

3423-1A-6

Human IFN-alpha2 ELISA development kit (ALP)

for 6 plates

3423-1H-20

Human IFN-alpha2 ELISA development kit (HRP)

for 20 plates

3423-1H-6

Human IFN-alpha2 ELISA development kit (HRP)

for 6 plates

IFN-alpha pan

3425-1A-20

Human IFN-alpha pan ELISA development kit (ALP)

for 20 plates

未包被

3425-1A-6

Human IFN-alpha pan ELISA development kit (ALP)

for 6 plates

3425-1H-20

Human IFN-alpha pan ELISA development kit (HRP)

for 20 plates

3425-1H-6

Human IFN-alpha pan ELISA development kit (HRP)

for 6 plates

IL-2

3445-1A-20

Human IL-2 ELISA development kit (ALP)

for 20 plates

未包被

3445-1A-6

Human IL-2 ELISA development kit (ALP)

for 6 plates

3445-1H-20

Human IL-2 ELISA development kit (HRP)

for 20 plates

3445-1H-6

Human IL-2 ELISA development kit (HRP)

for 6 plates

3445-1HP-10

Human IL-2 ELISAPRO kit

10 plates

已包被

3445-1HP-2

Human IL-2 ELISAPRO kit

2 plates

IL-12/-23 (p40)

3450-1A-20

Human IL-12/-23 (p40) ELISA development kit (ALP)

for 20 plates

未包被

3450-1A-6

Human IL-12/-23 (p40) ELISA development kit (ALP)

for 6 plates

3450-1H-20

Human IL-12/-23 (p40) ELISA development kit (HRP)

for 20 plates

3450-1H-6

Human IL-12/-23 (p40) ELISA development kit (HRP)

for 6 plates

3450-1HP-10

Human IL-12/-23 (p40) ELISAPRO kit

10 plates

已包被

3450-1HP-2

Human IL-12/-23 (p40) ELISAPRO kit

2 plates

IL-6

3460-1A-20

Human IL-6 ELISA development kit (ALP)

for 20 plates

未包被

3460-1A-6

Human IL-6 ELISA development kit (ALP)

for 6 plates

3460-1H-20

Human IL-6 ELISA development kit (HRP)

for 20 plates

3460-1H-6

Human IL-6 ELISA development kit (HRP)

for 6 plates

3460-1HP-10

Human IL-6 ELISAPRO kit

10 plates

已包被

3460-1HP-2

Human IL-6 ELISAPRO kit

2 plates

TNF-alpha

3512-1A-20

Human TNF-alpha ELISA development kit (ALP)

for 20 plates

未包被

3512-1A-6

Human TNF-alpha ELISA development kit (ALP)

for 6 plates

3512-1H-20

Human TNF-alpha ELISA development kit (HRP)

for 20 plates

3512-1H-6

Human TNF-alpha ELISA development kit (HRP)

for 6 plates

3512-1HP-10

Human TNF-alpha ELISAPRO kit

10 plates

已包被

3512-1HP-2

Human TNF-alpha ELISAPRO kit

2 plates

      莱兹自产ELISA试剂盒

抗病毒因子

货号

产品名称

规格

备注

IFN-α

LEH800-1

Human IFN-α ELISA KIT

48 tests

已包被

LEH800-2

Human IFN-α ELISA KIT

96 tests

IFN-α2

LEH801-1

Human IFN-α2 ELISA KIT

48 tests

LEH801-2

Human IFN-α2 ELISA KIT

96 tests

IFN-β

LEH802-1

Human IFN-β ELISA KIT

48 tests

LEH802-2

Human IFN-β ELISA KIT

96 tests

IFN-γ

LEH803-1

Human IFN-γ ELISA KIT

48 tests

LEH803-2

Human IFN-γ ELISA KIT

96 tests

LEH803-1H

Human IFN-γ High Sensitivity ELISA KIT

48 tests

LEH803-2H

Human IFN-γ High Sensitivity ELISA KIT

96 tests

IL-12/23p40

LEH121-1

Human IL-12/23p40 ELISA KIT

48 tests

LEH121-2

Human IL-12/23p40 ELISA KIT

96 tests

IL-18

LEH180-1

Human IL-18 ELISA KIT

48 tests

LEH180-2

Human IL-18 ELISA KIT

96 tests

IL-1β

LEH012-1

Human IL-1β ELISA KIT

48 tests

LEH012-2

Human IL-1β ELISA KIT

96 tests

IL-2

LEH020-1

Human IL-2 ELISA KIT

48 tests

LEH020-2

Human IL-2 ELISA KIT

96 tests

IL-4

LEH040-1

Human IL-4 ELISA KIT

48 tests

LEH040-2

Human IL-4 ELISA KIT

96 tests

LEH040-1H

Human IL-4 High Sensitivity ELISA KIT

48 tests

LEH040-2H

Human IL-4 High Sensitivity ELISA KIT

96 tests

IL-6

LEH060-1

Human IL-6 ELISA KIT

48 tests

LEH060-2

Human IL-6 ELISA KIT

96 tests

LEH060-1H

Human IL-6 High Sensitivity ELISA KIT

48 tests

LEH060-2H

Human IL-6 High Sensitivity ELISA KIT

96 tests

TNF-α

LEH810-1

Human TNF-α ELISA KIT

48 tests

LEH810-2

Human TNF-α ELISA KIT

96 tests

号

产品名称

规格

备注

IFN-α

LEH800-1

Human IFN-α ELISA KIT

48 tests

已包被

LEH800-2

Human IFN-α ELISA KIT

96 tests

IFN-α2

LEH801-1

Human IFN-α2 ELISA KIT

48 tests

LEH801-2

Human IFN-α2 ELISA KIT

96 tests

IFN-β

LEH802-1

Human IFN-β ELISA KIT

48 tests

LEH802-2

Human IFN-β ELISA KIT

96 tests

IFN-γ

LEH803-1

Human IFN-γ ELISA KIT

48 tests

LEH803-2

Human IFN-γ ELISA KIT

96 tests

LEH803-1H

Human IFN-γ High Sensitivity ELISA KIT

48 tests

LEH803-2H

Human IFN-γ High Sensitivity ELISA KIT

96 tests

IL-12/23p40

LEH121-1

Human IL-12/23p40 ELISA KIT

48 tests

LEH121-2

Human IL-12/23p40 ELISA KIT

96 tests

IL-18

LEH180-1

Human IL-18 ELISA KIT

48 tests

LEH180-2

Human IL-18 ELISA KIT

96 tests

IL-1β

LEH012-1

Human IL-1β ELISA KIT

48 tests

LEH012-2

Human IL-1β ELISA KIT

96 tests

IL-2

LEH020-1

Human IL-2 ELISA KIT

48 tests

LEH020-2

Human IL-2 ELISA KIT

96 tests

IL-4

LEH040-1

Human IL-4 ELISA KIT

48 tests

LEH040-2

Human IL-4 ELISA KIT

96 tests

LEH040-1H

Human IL-4 High Sensitivity ELISA KIT

48 tests

LEH040-2H

Human IL-4 High Sensitivity ELISA KIT

96 tests

IL-6

LEH060-1

Human IL-6 ELISA KIT

48 tests

LEH060-2

Human IL-6 ELISA KIT

96 tests

LEH060-1H

Human IL-6 High Sensitivity ELISA KIT

48 tests

LEH060-2H

Human IL-6 High Sensitivity ELISA KIT

96 tests

TNF-α

LEH810-1

Human TNF-α ELISA KIT

48 tests

LEH810-2

Human TNF-α ELISA KIT

96 tests
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